Infections, such as Lyme disease, shingles, hepatitis B and C, and HIV.Low levels of vitamins in the body, especially vitamin B-12.Diabetes, especially if your sugar levels are not controlled well.Peripheral neuropathy risk factors include: Hypothyroidism: Can it cause peripheral neuropathy?.Peripheral neuropathy care at Mayo Clinic.This is called idiopathic peripheral neuropathy. In some cases, no cause can be identified. B vitamins, including B-1, B-6 and B-12, as well as copper and vitamin E are crucial to nerve health. Nerve pressure can result from having a cast or using crutches or repeating a motion such as typing many times. Injuries, such as from motor vehicle accidents, falls or sports injuries, can sever or damage peripheral nerves. Certain medicines, especially chemotherapy used to treat cancer, can cause peripheral neuropathy. Toxic substances include industrial chemicals and heavy metals such as lead and mercury. Unhealthy dietary choices made by people with alcohol use disorder, also known as alcoholism, and poor absorption of vitamins can lead to low amounts of essential vitamins in the body. These include metabolic conditions such as kidney disease or liver disease, and an underactive thyroid, also known as hypothyroidism. These include a protein in the blood that isn't usually there, called monoclonal gammopathies, a form of bone cancer called myeloma, lymphoma and the rare disease amyloidosis. Cancerous growths, also called malignant, and noncancerous growths, also called benign, can grow on or press on nerves. Disorders such as Charcot-Marie-Tooth disease are hereditary types of neuropathy that run in families. These include certain viral or bacterial infections, including Lyme disease, shingles, hepatitis B and C, leprosy, diphtheria, and HIV. Among people with diabetes, more than half will develop some type of neuropathy. These are a form of autoimmune disorder called paraneoplastic syndrome. Also, some cancers related to the body's immune system can cause polyneuropathy. These include Sjogren's syndrome, lupus, rheumatoid arthritis, Guillain-Barre syndrome, chronic inflammatory demyelinating polyneuropathy and vasculitis. Health conditions that can cause peripheral neuropathy include: Peripheral neuropathy is nerve damage caused by several different conditions. Early diagnosis and treatment give you the best chance for controlling your symptoms and preventing further damage to your peripheral nerves. Seek medical care right away if you notice unusual tingling, weakness, or pain in your hands or feet. Most people with peripheral neuropathy have polyneuropathy. Carpal tunnel syndrome is an example of mononeuropathy. If it affects two or more nerves in different areas, it's called multiple mononeuropathy, and if it affects many nerves, it's called polyneuropathy. Peripheral neuropathy can affect one nerve, called mononeuropathy. Drops in blood pressure, causing dizziness or lightheadedness.Excessive sweating or not being able to sweat.If autonomic nerves are affected, symptoms might include: Inability to move if motor nerves are affected.Feeling as if you're wearing gloves or socks when you're not.Pain during activities that shouldn't cause pain, such as pain in your feet when putting weight on them or when they're under a blanket.Sharp, jabbing, throbbing or burning pain.These sensations can spread upward into your legs and arms. Gradual onset of numbness, prickling, or tingling in your feet or hands.Symptoms of peripheral neuropathy might include: Autonomic nerves that control functions such as blood pressure, sweating, heart rate, digestion and bladder function.Motor nerves that control muscle movement.Sensory nerves that receive sensation, such as temperature, pain, vibration or touch, from the skin.Symptoms depend on the type of nerves affected.
Every nerve in the peripheral system has a specific job.
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